An example of TargetMine application

Suppose we would like to answer the following questions:

Given a list of genes, identify all the diseases which they are associated with and all the drugs which target these genes.

1. First, start by uploading a list.

(If your don’t know how to upload a list, see the ‘Lists‘ page.)

List analysis page

List analysis page

2. To answer which diseases are associated with the genes in the list, you can search the template (predefined query) by the keyword ‘disease’.

(If your don’t know how to use the templates, see the ‘Templates‘ page.)

Filter templates by th keyword 'disease'

Filter templates by the keyword ‘disease’

3. You can find the template ‘Gene(s) –> Disease(s)’ templates. Constrain to the genes in your uploaded list and run the query.

Constrain to a gene list for a template query.

Constrain to a gene list for a template query.

The query results show those diseases associated with the genes in the list.

The query results show those diseases associated with the genes in the list.

4. For compounds which target these genes, you can use the same approach to find the template, ‘Gene(s) –> Compounds’ and run the query.

Genes --> compounds template.

Genes –> compounds template.