Given a list of genes, identify all the interacting genes and the druggabilities of these interactions.
Hub is defined as the top 10% of the nodes in the high-confidence protein interactome ranked by node degree (the number of interactions that are associated with a given node).
Bottleneck is defined as the top 10% of the nodes in the high-confidence protein interactome ranked by betweenness centrality (the fraction of all the shortest paths in an interactome that pass through a given node).
High-confidence PPI here implies that the interaction was validated by more than 2 experiment methods or reported by more than 2 publications.
Check the references for the application and more details.
- Tripathi LP, et al. (2013) Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach. J Proteome Res. [PubMed:23682656]
- Betweenness centrality is an indicator of a node’s centrality in a network. It is equal to the number of shortest paths from all vertices to all others that pass through that node. [Wikipedia: Betweenness centrality]