Target prioritization which means to identify suitable targets (such as genes, proteins, non-peptide gene products and pathways) for characterization, is one of the most critical steps in biology, particularly in annotating gene function, drug discovery and understanding molecular bases of diseases. Here, the prioritization does not attempt to order the candidates but to distinguish or to narrow down fewer candidates from a lot of them.
We have proposed a prioritization protocol using TargetMine (Chen et al., 2011).
A brief flow chart of target prioritization.
Benchmarking
Here are some slides displaying the benchmarking process for gene prioritization described in the paper.
- Please see the on-line slides here .
Other applications could be found in “Applications of TargetMine“.
